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Additionally, AMPK activation increases the rate of fatty acid oxidation by enhancing glucose uptake and oxidation in skeletal muscle cells (ONeill et al., 2013), and this may be related to the improvement of the insulin resistance state of the body through the regulation of PGC-1 to promote the activity of the mitochondrial oxidative respiratory chain (Kukidome et al., 2006)

Anelli, T

A more appropriate diagnosis for this situation is focal necrosis (see the following)

In conclusion, our data imply combined targeting of glutaminolysis and one-carbon metabolism could be efficient in enhancing chemotherapy efficacy by accumulating ROS for ATC